Previous results demonstrated the role of Collaxyl in the systhesis of a rich ECM on which cells differentiat better and express optimal protein synthesis.
Results Ex. vivo H&E staining
Objective
Collaxyl, untreated skin
The purpose of the study was to investigate the effect of Collaxyl on skin repair processes, using an ex vivo model of experimental wound healing.
Method
Collaxyl was applied at 1% on the dermis side of 3 mm punch biopsies, for 10 seconds. 2 biopsies were placed right next to each other on the same insert. Inserts kept biopsies at the ir-medium interface. Control, untreated skin biopsies were placed on inserts in the same conditions. Treated and untreated skin samples were cultured for 3 days and then prepared for standard H&E staining and microscope observation.
Collaxyl-treated skin
Results
Treated skin eshibited a remarkable better epidermal and dermal structre than control samples. The epidermis showed a complete repair and healing with no signs of stress, and the dermis showed an advanced healing and had a superior fibrillar structure in Collaxul-treated samples.
Conclusion
Studies on experimentally-induced full-thickness skin wounds show that Collaxyl-treated skin exhibits complete and rapid epidermal regeneration and repair compared to untreated skin.